SUMMARY
Abstract
This study investigates the histologic effects of dermal and subdermal tissue remodeling following a single treatment with radiofrequency macroneedling (Morpheus8, InMode). Biopsies from patients demonstrated structural age-related skin changes before treatment. Four weeks post-treatment, histology revealed significant improvements including increased collagen density, elastin regeneration, fibroblast activity, and vascularization, with reduced inflammatory cell presence. These findings confirm the ability of RF macroneedling to induce extracellular matrix remodeling and skin tightening.
Conclusion
Radiofrequency macroneedling with Morpheus8 induces marked dermal and subdermal rejuvenation, effectively correcting age-related changes such as wrinkles, skin laxity, and textural irregularities. The study demonstrates significant “subsurfacing” thermal remodeling with collagen and elastin improvement, confirming RF macroneedling as a safe and effective modality for facial skin rejuvenation. A larger sample size is recommended to validate these promising findings.
TOPICS COVERED
- Use of Morpheus8 RF macroneedling for dermal and subdermal remodeling
- Histologic evaluation of collagen and elastin changes post-treatment
- Role of fibroblast activation and neovascularization in skin rejuvenation
- Reduction of inflammatory markers and improvement in skin quality
- Demonstration of subsurfacing thermal remodeling unique to Morpheus8
- Clinical implications for correcting wrinkles, laxity, and scars
